The Chinese herbal formula Xuanju was found to protect sperm against chromatin damage and significantly improve sperm’s DNA Fragmentation Index (DFI). This is very important because most semen analyses don’t look at the DFI. You can have “normal” sperm from a sperm analysis yet in reality the sperm has a very low chance of producing a pregnancy. Unfortunately we see this all too often, where the male assumes his sperm is fine and it isn’t. This can greatly slow down or halt one’s ability to get pregnant. To make matters worse, if IVF is done and they use ICSI, sperm are chosen based on their looks. You cannot see DNA fragmentation in the sperm. Therefore, this is something that can cause a very expensive procedure to fail.
The good news is that herbal medicine has been shown to improve sperm’s DNA integrity. The vitamin E by itself did not improve the DNA integrity.
Zhonghua Nan Ke Xue. 2012 Dec;18(12):1105-7. Compound Xuanju Capsule combined with vitamin E improves sperm chromatin integrity.